Serological profiling of the EBV immune response in Chronic Fatigue Syndrome using a peptide microarray
Identifieur interne : 000B94 ( Main/Exploration ); précédent : 000B93; suivant : 000B95Serological profiling of the EBV immune response in Chronic Fatigue Syndrome using a peptide microarray
Auteurs : Madlen Loebel [Allemagne] ; Maren Eckey [Allemagne] ; Franziska Sotzny [Allemagne] ; Elisabeth Hahn [Allemagne] ; Sandra Bauer [Allemagne] ; Patricia Grabowski [Allemagne] ; Johannes Zerweck [Allemagne] ; Pavlo Holenya [Allemagne] ; Leif G. Hanitsch [Allemagne] ; Kirsten Wittke [Allemagne] ; Peter Borchmann [Allemagne] ; Jens-Ulrich Rüffer [Allemagne] ; Falk Hiepe [Allemagne] ; Klemens Ruprecht [Allemagne] ; Uta Behrends [Allemagne] ; Carola Meindl [Allemagne] ; Hans-Dieter Volk [Allemagne] ; Ulf Reimer [Allemagne] ; Carmen Scheibenbogen [Allemagne]Source :
- PLoS ONE [ 1932-6203 ] ; 2017.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Analyse par réseau de protéines, Anticorps antiviraux (immunologie), Anticorps antiviraux (sang), Antigènes viraux (immunologie), Charge virale, Femelle, Herpèsvirus humain de type 4 (), Herpèsvirus humain de type 4 (génétique), Herpèsvirus humain de type 4 (immunologie), Humains, Immunoglobuline G (immunologie), Immunoglobuline G (sang), Infections à virus Epstein-Barr (), Infections à virus Epstein-Barr (immunologie), Infections à virus Epstein-Barr (sang), Infections à virus Epstein-Barr (virologie), Marqueurs biologiques, Mâle, Prévalence, Réactions croisées, Syndrome de fatigue chronique (), Syndrome de fatigue chronique (immunologie), Syndrome de fatigue chronique (sang), Syndrome de fatigue chronique (épidémiologie), Test ELISA, Épitopes (immunologie).
- MESH :
- génétique : Herpèsvirus humain de type 4.
- immunologie : Anticorps antiviraux, Antigènes viraux, Herpèsvirus humain de type 4, Immunoglobuline G, Infections à virus Epstein-Barr, Syndrome de fatigue chronique, Épitopes.
- sang : Anticorps antiviraux, Immunoglobuline G, Infections à virus Epstein-Barr, Syndrome de fatigue chronique.
- virologie : Infections à virus Epstein-Barr.
- épidémiologie : Syndrome de fatigue chronique.
- Adulte, Adulte d'âge moyen, Analyse par réseau de protéines, Charge virale, Femelle, Herpèsvirus humain de type 4, Humains, Infections à virus Epstein-Barr, Marqueurs biologiques, Mâle, Prévalence, Réactions croisées, Syndrome de fatigue chronique, Test ELISA.
English descriptors
- KwdEn :
- Adult, Antibodies, Viral (blood), Antibodies, Viral (immunology), Antigens, Viral (immunology), Biomarkers, Cross Reactions, Enzyme-Linked Immunosorbent Assay, Epitopes (immunology), Epstein-Barr Virus Infections (blood), Epstein-Barr Virus Infections (complications), Epstein-Barr Virus Infections (immunology), Epstein-Barr Virus Infections (virology), Fatigue Syndrome, Chronic (blood), Fatigue Syndrome, Chronic (complications), Fatigue Syndrome, Chronic (epidemiology), Fatigue Syndrome, Chronic (immunology), Female, Herpesvirus 4, Human (classification), Herpesvirus 4, Human (genetics), Herpesvirus 4, Human (immunology), Humans, Immunoglobulin G (blood), Immunoglobulin G (immunology), Male, Middle Aged, Prevalence, Protein Array Analysis, Viral Load.
- MESH :
- chemical , blood : Antibodies, Viral, Immunoglobulin G.
- chemical , immunology : Antibodies, Viral, Antigens, Viral, Epitopes, Immunoglobulin G.
- blood : Epstein-Barr Virus Infections, Fatigue Syndrome, Chronic.
- classification : Herpesvirus 4, Human.
- complications : Epstein-Barr Virus Infections, Fatigue Syndrome, Chronic.
- epidemiology : Fatigue Syndrome, Chronic.
- genetics : Herpesvirus 4, Human.
- immunology : Epstein-Barr Virus Infections, Fatigue Syndrome, Chronic, Herpesvirus 4, Human.
- virology : Epstein-Barr Virus Infections.
- Adult, Biomarkers, Cross Reactions, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Middle Aged, Prevalence, Protein Array Analysis, Viral Load.
Abstract
Epstein-Barr-Virus (EBV) plays an important role as trigger or cofactor for various autoimmune diseases. In a subset of patients with Chronic Fatigue Syndrome (CFS) disease starts with infectious mononucleosis as late primary EBV-infection, whereby altered levels of EBV-specific antibodies can be observed in another subset of patients.
We performed a comprehensive mapping of the IgG response against EBV comparing 50 healthy controls with 92 CFS patients using a microarray platform. Patients with multiple sclerosis (MS), systemic lupus erythematosus (SLE) and cancer-related fatigue served as controls. 3054 overlapping peptides were synthesised as 15-mers from 14 different EBV proteins. Array data was validated by ELISA for selected peptides. Prevalence of EBV serotypes was determined by qPCR from throat washing samples.
EBV type 1 infections were found in patients and controls. EBV seroarray profiles between healthy controls and CFS were less divergent than that observed for MS or SLE. We found significantly enhanced IgG responses to several EBNA-6 peptides containing a repeat sequence in CFS patients compared to controls. EBNA-6 peptide IgG responses correlated well with EBNA-6 protein responses. The EBNA-6 repeat region showed sequence homologies to various human proteins.
Patients with CFS had a quite similar EBV IgG antibody response pattern as healthy controls. Enhanced IgG reactivity against an EBNA-6 repeat sequence and against EBNA-6 protein is found in CFS patients. Homologous sequences of various human proteins with this EBNA-6 repeat sequence might be potential targets for antigenic mimicry.
Url:
DOI: 10.1371/journal.pone.0179124
PubMed: 28604802
PubMed Central: 5467847
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001029
- to stream Pmc, to step Curation: 001029
- to stream Pmc, to step Checkpoint: 000723
- to stream PubMed, to step Corpus: 000C66
- to stream PubMed, to step Curation: 000C66
- to stream PubMed, to step Checkpoint: 000B34
- to stream Ncbi, to step Merge: 001A68
- to stream Ncbi, to step Curation: 001A68
- to stream Ncbi, to step Checkpoint: 001A68
- to stream Main, to step Merge: 000B97
- to stream Main, to step Curation: 000B94
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Serological profiling of the EBV immune response in Chronic Fatigue Syndrome using a peptide microarray</title><author><name sortKey="Loebel, Madlen" sort="Loebel, Madlen" uniqKey="Loebel M" first="Madlen" last="Loebel">Madlen Loebel</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Medical Immunology, Charité University Medicine Berlin, Campus Virchow, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Immunology, Charité University Medicine Berlin, Campus Virchow, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Eckey, Maren" sort="Eckey, Maren" uniqKey="Eckey M" first="Maren" last="Eckey">Maren Eckey</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>JPT Peptide Technologies GmbH, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>JPT Peptide Technologies GmbH, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Sotzny, Franziska" sort="Sotzny, Franziska" uniqKey="Sotzny F" first="Franziska" last="Sotzny">Franziska Sotzny</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Medical Immunology, Charité University Medicine Berlin, Campus Virchow, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Immunology, Charité University Medicine Berlin, Campus Virchow, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Hahn, Elisabeth" sort="Hahn, Elisabeth" uniqKey="Hahn E" first="Elisabeth" last="Hahn">Elisabeth Hahn</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Medical Immunology, Charité University Medicine Berlin, Campus Virchow, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Immunology, Charité University Medicine Berlin, Campus Virchow, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Bauer, Sandra" sort="Bauer, Sandra" uniqKey="Bauer S" first="Sandra" last="Bauer">Sandra Bauer</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Medical Immunology, Charité University Medicine Berlin, Campus Virchow, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Immunology, Charité University Medicine Berlin, Campus Virchow, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Grabowski, Patricia" sort="Grabowski, Patricia" uniqKey="Grabowski P" first="Patricia" last="Grabowski">Patricia Grabowski</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Medical Immunology, Charité University Medicine Berlin, Campus Virchow, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Immunology, Charité University Medicine Berlin, Campus Virchow, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Zerweck, Johannes" sort="Zerweck, Johannes" uniqKey="Zerweck J" first="Johannes" last="Zerweck">Johannes Zerweck</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>JPT Peptide Technologies GmbH, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>JPT Peptide Technologies GmbH, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Holenya, Pavlo" sort="Holenya, Pavlo" uniqKey="Holenya P" first="Pavlo" last="Holenya">Pavlo Holenya</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>JPT Peptide Technologies GmbH, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>JPT Peptide Technologies GmbH, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Hanitsch, Leif G" sort="Hanitsch, Leif G" uniqKey="Hanitsch L" first="Leif G." last="Hanitsch">Leif G. Hanitsch</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Medical Immunology, Charité University Medicine Berlin, Campus Virchow, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Immunology, Charité University Medicine Berlin, Campus Virchow, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Wittke, Kirsten" sort="Wittke, Kirsten" uniqKey="Wittke K" first="Kirsten" last="Wittke">Kirsten Wittke</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Medical Immunology, Charité University Medicine Berlin, Campus Virchow, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Immunology, Charité University Medicine Berlin, Campus Virchow, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Borchmann, Peter" sort="Borchmann, Peter" uniqKey="Borchmann P" first="Peter" last="Borchmann">Peter Borchmann</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany and German Hodgkin Study Group (GHSG), Cologne, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany and German Hodgkin Study Group (GHSG), Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Ruffer, Jens Ulrich" sort="Ruffer, Jens Ulrich" uniqKey="Ruffer J" first="Jens-Ulrich" last="Rüffer">Jens-Ulrich Rüffer</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>German Fatigue Society e.V. (DFaG), Cologne, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Fatigue Society e.V. (DFaG), Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Hiepe, Falk" sort="Hiepe, Falk" uniqKey="Hiepe F" first="Falk" last="Hiepe">Falk Hiepe</name><affiliation wicri:level="3"><nlm:aff id="aff005"><addr-line>Department of Rheumatology and Clinical Immunology, Charité University Medicine Berlin, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Rheumatology and Clinical Immunology, Charité University Medicine Berlin, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Ruprecht, Klemens" sort="Ruprecht, Klemens" uniqKey="Ruprecht K" first="Klemens" last="Ruprecht">Klemens Ruprecht</name><affiliation wicri:level="3"><nlm:aff id="aff006"><addr-line>Department of Neurology and Clinical and Experimental Multiple Sclerosis Research Center, Charité University Medicine Berlin, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology and Clinical and Experimental Multiple Sclerosis Research Center, Charité University Medicine Berlin, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Behrends, Uta" sort="Behrends, Uta" uniqKey="Behrends U" first="Uta" last="Behrends">Uta Behrends</name><affiliation wicri:level="4"><nlm:aff id="aff007"><addr-line>Children’s Hospital Schwabing, Technische Universität München (TUM), Munich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Children’s Hospital Schwabing, Technische Universität München (TUM), Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff008"><addr-line>Department of Gene Vectors, Helmholtz Center Munich (HMGU), Munich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Gene Vectors, Helmholtz Center Munich (HMGU), Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff009"><addr-line>German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Infection Research (DZIF), Partner Site Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Meindl, Carola" sort="Meindl, Carola" uniqKey="Meindl C" first="Carola" last="Meindl">Carola Meindl</name><affiliation wicri:level="4"><nlm:aff id="aff007"><addr-line>Children’s Hospital Schwabing, Technische Universität München (TUM), Munich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Children’s Hospital Schwabing, Technische Universität München (TUM), Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff008"><addr-line>Department of Gene Vectors, Helmholtz Center Munich (HMGU), Munich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Gene Vectors, Helmholtz Center Munich (HMGU), Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Volk, Hans Dieter" sort="Volk, Hans Dieter" uniqKey="Volk H" first="Hans-Dieter" last="Volk">Hans-Dieter Volk</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Medical Immunology, Charité University Medicine Berlin, Campus Virchow, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Immunology, Charité University Medicine Berlin, Campus Virchow, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff010"><addr-line>Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité University Medicine Berlin, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité University Medicine Berlin, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Reimer, Ulf" sort="Reimer, Ulf" uniqKey="Reimer U" first="Ulf" last="Reimer">Ulf Reimer</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>JPT Peptide Technologies GmbH, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>JPT Peptide Technologies GmbH, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Scheibenbogen, Carmen" sort="Scheibenbogen, Carmen" uniqKey="Scheibenbogen C" first="Carmen" last="Scheibenbogen">Carmen Scheibenbogen</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Medical Immunology, Charité University Medicine Berlin, Campus Virchow, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Immunology, Charité University Medicine Berlin, Campus Virchow, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff010"><addr-line>Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité University Medicine Berlin, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité University Medicine Berlin, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28604802</idno><idno type="pmc">5467847</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467847</idno><idno type="RBID">PMC:5467847</idno><idno type="doi">10.1371/journal.pone.0179124</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">001029</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001029</idno><idno type="wicri:Area/Pmc/Curation">001029</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001029</idno><idno type="wicri:Area/Pmc/Checkpoint">000723</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000723</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:28604802</idno><idno type="wicri:Area/PubMed/Corpus">000C66</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000C66</idno><idno type="wicri:Area/PubMed/Curation">000C66</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000C66</idno><idno type="wicri:Area/PubMed/Checkpoint">000B34</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000B34</idno><idno type="wicri:Area/Ncbi/Merge">001A68</idno><idno type="wicri:Area/Ncbi/Curation">001A68</idno><idno type="wicri:Area/Ncbi/Checkpoint">001A68</idno><idno type="wicri:Area/Main/Merge">000B97</idno><idno type="wicri:Area/Main/Curation">000B94</idno><idno type="wicri:Area/Main/Exploration">000B94</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Serological profiling of the EBV immune response in Chronic Fatigue Syndrome using a peptide microarray</title><author><name sortKey="Loebel, Madlen" sort="Loebel, Madlen" uniqKey="Loebel M" first="Madlen" last="Loebel">Madlen Loebel</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Medical Immunology, Charité University Medicine Berlin, Campus Virchow, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Immunology, Charité University Medicine Berlin, Campus Virchow, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Eckey, Maren" sort="Eckey, Maren" uniqKey="Eckey M" first="Maren" last="Eckey">Maren Eckey</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>JPT Peptide Technologies GmbH, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>JPT Peptide Technologies GmbH, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Sotzny, Franziska" sort="Sotzny, Franziska" uniqKey="Sotzny F" first="Franziska" last="Sotzny">Franziska Sotzny</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Medical Immunology, Charité University Medicine Berlin, Campus Virchow, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Immunology, Charité University Medicine Berlin, Campus Virchow, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Hahn, Elisabeth" sort="Hahn, Elisabeth" uniqKey="Hahn E" first="Elisabeth" last="Hahn">Elisabeth Hahn</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Medical Immunology, Charité University Medicine Berlin, Campus Virchow, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Immunology, Charité University Medicine Berlin, Campus Virchow, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Bauer, Sandra" sort="Bauer, Sandra" uniqKey="Bauer S" first="Sandra" last="Bauer">Sandra Bauer</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Medical Immunology, Charité University Medicine Berlin, Campus Virchow, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Immunology, Charité University Medicine Berlin, Campus Virchow, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Grabowski, Patricia" sort="Grabowski, Patricia" uniqKey="Grabowski P" first="Patricia" last="Grabowski">Patricia Grabowski</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Medical Immunology, Charité University Medicine Berlin, Campus Virchow, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Immunology, Charité University Medicine Berlin, Campus Virchow, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Zerweck, Johannes" sort="Zerweck, Johannes" uniqKey="Zerweck J" first="Johannes" last="Zerweck">Johannes Zerweck</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>JPT Peptide Technologies GmbH, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>JPT Peptide Technologies GmbH, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Holenya, Pavlo" sort="Holenya, Pavlo" uniqKey="Holenya P" first="Pavlo" last="Holenya">Pavlo Holenya</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>JPT Peptide Technologies GmbH, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>JPT Peptide Technologies GmbH, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Hanitsch, Leif G" sort="Hanitsch, Leif G" uniqKey="Hanitsch L" first="Leif G." last="Hanitsch">Leif G. Hanitsch</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Medical Immunology, Charité University Medicine Berlin, Campus Virchow, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Immunology, Charité University Medicine Berlin, Campus Virchow, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Wittke, Kirsten" sort="Wittke, Kirsten" uniqKey="Wittke K" first="Kirsten" last="Wittke">Kirsten Wittke</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Medical Immunology, Charité University Medicine Berlin, Campus Virchow, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Immunology, Charité University Medicine Berlin, Campus Virchow, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Borchmann, Peter" sort="Borchmann, Peter" uniqKey="Borchmann P" first="Peter" last="Borchmann">Peter Borchmann</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany and German Hodgkin Study Group (GHSG), Cologne, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany and German Hodgkin Study Group (GHSG), Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Ruffer, Jens Ulrich" sort="Ruffer, Jens Ulrich" uniqKey="Ruffer J" first="Jens-Ulrich" last="Rüffer">Jens-Ulrich Rüffer</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>German Fatigue Society e.V. (DFaG), Cologne, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Fatigue Society e.V. (DFaG), Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Hiepe, Falk" sort="Hiepe, Falk" uniqKey="Hiepe F" first="Falk" last="Hiepe">Falk Hiepe</name><affiliation wicri:level="3"><nlm:aff id="aff005"><addr-line>Department of Rheumatology and Clinical Immunology, Charité University Medicine Berlin, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Rheumatology and Clinical Immunology, Charité University Medicine Berlin, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Ruprecht, Klemens" sort="Ruprecht, Klemens" uniqKey="Ruprecht K" first="Klemens" last="Ruprecht">Klemens Ruprecht</name><affiliation wicri:level="3"><nlm:aff id="aff006"><addr-line>Department of Neurology and Clinical and Experimental Multiple Sclerosis Research Center, Charité University Medicine Berlin, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology and Clinical and Experimental Multiple Sclerosis Research Center, Charité University Medicine Berlin, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Behrends, Uta" sort="Behrends, Uta" uniqKey="Behrends U" first="Uta" last="Behrends">Uta Behrends</name><affiliation wicri:level="4"><nlm:aff id="aff007"><addr-line>Children’s Hospital Schwabing, Technische Universität München (TUM), Munich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Children’s Hospital Schwabing, Technische Universität München (TUM), Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff008"><addr-line>Department of Gene Vectors, Helmholtz Center Munich (HMGU), Munich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Gene Vectors, Helmholtz Center Munich (HMGU), Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff009"><addr-line>German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Infection Research (DZIF), Partner Site Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Meindl, Carola" sort="Meindl, Carola" uniqKey="Meindl C" first="Carola" last="Meindl">Carola Meindl</name><affiliation wicri:level="4"><nlm:aff id="aff007"><addr-line>Children’s Hospital Schwabing, Technische Universität München (TUM), Munich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Children’s Hospital Schwabing, Technische Universität München (TUM), Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff008"><addr-line>Department of Gene Vectors, Helmholtz Center Munich (HMGU), Munich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Gene Vectors, Helmholtz Center Munich (HMGU), Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Volk, Hans Dieter" sort="Volk, Hans Dieter" uniqKey="Volk H" first="Hans-Dieter" last="Volk">Hans-Dieter Volk</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Medical Immunology, Charité University Medicine Berlin, Campus Virchow, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Immunology, Charité University Medicine Berlin, Campus Virchow, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff010"><addr-line>Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité University Medicine Berlin, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité University Medicine Berlin, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Reimer, Ulf" sort="Reimer, Ulf" uniqKey="Reimer U" first="Ulf" last="Reimer">Ulf Reimer</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>JPT Peptide Technologies GmbH, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>JPT Peptide Technologies GmbH, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Scheibenbogen, Carmen" sort="Scheibenbogen, Carmen" uniqKey="Scheibenbogen C" first="Carmen" last="Scheibenbogen">Carmen Scheibenbogen</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Medical Immunology, Charité University Medicine Berlin, Campus Virchow, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Immunology, Charité University Medicine Berlin, Campus Virchow, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff010"><addr-line>Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité University Medicine Berlin, Berlin, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité University Medicine Berlin, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antibodies, Viral (blood)</term><term>Antibodies, Viral (immunology)</term><term>Antigens, Viral (immunology)</term><term>Biomarkers</term><term>Cross Reactions</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Epitopes (immunology)</term><term>Epstein-Barr Virus Infections (blood)</term><term>Epstein-Barr Virus Infections (complications)</term><term>Epstein-Barr Virus Infections (immunology)</term><term>Epstein-Barr Virus Infections (virology)</term><term>Fatigue Syndrome, Chronic (blood)</term><term>Fatigue Syndrome, Chronic (complications)</term><term>Fatigue Syndrome, Chronic (epidemiology)</term><term>Fatigue Syndrome, Chronic (immunology)</term><term>Female</term><term>Herpesvirus 4, Human (classification)</term><term>Herpesvirus 4, Human (genetics)</term><term>Herpesvirus 4, Human (immunology)</term><term>Humans</term><term>Immunoglobulin G (blood)</term><term>Immunoglobulin G (immunology)</term><term>Male</term><term>Middle Aged</term><term>Prevalence</term><term>Protein Array Analysis</term><term>Viral Load</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse par réseau de protéines</term><term>Anticorps antiviraux (immunologie)</term><term>Anticorps antiviraux (sang)</term><term>Antigènes viraux (immunologie)</term><term>Charge virale</term><term>Femelle</term><term>Herpèsvirus humain de type 4 ()</term><term>Herpèsvirus humain de type 4 (génétique)</term><term>Herpèsvirus humain de type 4 (immunologie)</term><term>Humains</term><term>Immunoglobuline G (immunologie)</term><term>Immunoglobuline G (sang)</term><term>Infections à virus Epstein-Barr ()</term><term>Infections à virus Epstein-Barr (immunologie)</term><term>Infections à virus Epstein-Barr (sang)</term><term>Infections à virus Epstein-Barr (virologie)</term><term>Marqueurs biologiques</term><term>Mâle</term><term>Prévalence</term><term>Réactions croisées</term><term>Syndrome de fatigue chronique ()</term><term>Syndrome de fatigue chronique (immunologie)</term><term>Syndrome de fatigue chronique (sang)</term><term>Syndrome de fatigue chronique (épidémiologie)</term><term>Test ELISA</term><term>Épitopes (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Viral</term><term>Antigens, Viral</term><term>Epitopes</term><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Epstein-Barr Virus Infections</term><term>Fatigue Syndrome, Chronic</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Herpesvirus 4, Human</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Epstein-Barr Virus Infections</term><term>Fatigue Syndrome, Chronic</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Fatigue Syndrome, Chronic</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Herpesvirus 4, Human</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Herpèsvirus humain de type 4</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term><term>Antigènes viraux</term><term>Herpèsvirus humain de type 4</term><term>Immunoglobuline G</term><term>Infections à virus Epstein-Barr</term><term>Syndrome de fatigue chronique</term><term>Épitopes</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Epstein-Barr Virus Infections</term><term>Fatigue Syndrome, Chronic</term><term>Herpesvirus 4, Human</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term><term>Immunoglobuline G</term><term>Infections à virus Epstein-Barr</term><term>Syndrome de fatigue chronique</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à virus Epstein-Barr</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Epstein-Barr Virus Infections</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Syndrome de fatigue chronique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Biomarkers</term><term>Cross Reactions</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prevalence</term><term>Protein Array Analysis</term><term>Viral Load</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse par réseau de protéines</term><term>Charge virale</term><term>Femelle</term><term>Herpèsvirus humain de type 4</term><term>Humains</term><term>Infections à virus Epstein-Barr</term><term>Marqueurs biologiques</term><term>Mâle</term><term>Prévalence</term><term>Réactions croisées</term><term>Syndrome de fatigue chronique</term><term>Test ELISA</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Background</title><p>Epstein-Barr-Virus (EBV) plays an important role as trigger or cofactor for various autoimmune diseases. In a subset of patients with Chronic Fatigue Syndrome (CFS) disease starts with infectious mononucleosis as late primary EBV-infection, whereby altered levels of EBV-specific antibodies can be observed in another subset of patients.</p></sec><sec id="sec002"><title>Methods</title><p>We performed a comprehensive mapping of the IgG response against EBV comparing 50 healthy controls with 92 CFS patients using a microarray platform. Patients with multiple sclerosis (MS), systemic lupus erythematosus (SLE) and cancer-related fatigue served as controls. 3054 overlapping peptides were synthesised as 15-mers from 14 different EBV proteins. Array data was validated by ELISA for selected peptides. Prevalence of EBV serotypes was determined by qPCR from throat washing samples.</p></sec><sec id="sec003"><title>Results</title><p>EBV type 1 infections were found in patients and controls. EBV seroarray profiles between healthy controls and CFS were less divergent than that observed for MS or SLE. We found significantly enhanced IgG responses to several EBNA-6 peptides containing a repeat sequence in CFS patients compared to controls. EBNA-6 peptide IgG responses correlated well with EBNA-6 protein responses. The EBNA-6 repeat region showed sequence homologies to various human proteins.</p></sec><sec id="sec004"><title>Conclusion</title><p>Patients with CFS had a quite similar EBV IgG antibody response pattern as healthy controls. Enhanced IgG reactivity against an EBNA-6 repeat sequence and against EBNA-6 protein is found in CFS patients. Homologous sequences of various human proteins with this EBNA-6 repeat sequence might be potential targets for antigenic mimicry.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Gross, Aj" uniqKey="Gross A">AJ Gross</name></author><author><name sortKey="Hochberg, D" uniqKey="Hochberg D">D Hochberg</name></author><author><name sortKey="Rand, Wm" uniqKey="Rand W">WM Rand</name></author><author><name sortKey="Thorley Lawson, Da" uniqKey="Thorley Lawson D">DA Thorley-Lawson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kang, I" uniqKey="Kang I">I Kang</name></author><author><name sortKey="Quan, T" uniqKey="Quan T">T Quan</name></author><author><name sortKey="Nolasco, H" uniqKey="Nolasco H">H Nolasco</name></author><author><name sortKey="Park, Sh" uniqKey="Park S">SH Park</name></author><author><name sortKey="Hong, Ms" uniqKey="Hong M">MS Hong</name></author><author><name sortKey="Crouch, J" uniqKey="Crouch J">J Crouch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Balandraud, N" uniqKey="Balandraud N">N Balandraud</name></author><author><name sortKey="Meynard, Jb" uniqKey="Meynard J">JB Meynard</name></author><author><name sortKey="Auger, I" uniqKey="Auger I">I Auger</name></author><author><name sortKey="Sovran, H" uniqKey="Sovran H">H Sovran</name></author><author><name sortKey="Mugnier, B" uniqKey="Mugnier B">B Mugnier</name></author><author><name sortKey="Reviron, D" uniqKey="Reviron D">D Reviron</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blaschke, S" uniqKey="Blaschke S">S Blaschke</name></author><author><name sortKey="Schwarz, G" uniqKey="Schwarz G">G Schwarz</name></author><author><name sortKey="Moneke, D" uniqKey="Moneke D">D Moneke</name></author><author><name sortKey="Binder, L" uniqKey="Binder L">L Binder</name></author><author><name sortKey="Muller, G" uniqKey="Muller G">G Muller</name></author><author><name sortKey="Reuss Borst, M" uniqKey="Reuss Borst M">M Reuss-Borst</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pasoto, Sg" uniqKey="Pasoto S">SG Pasoto</name></author><author><name sortKey="Natalino, Rr" uniqKey="Natalino R">RR Natalino</name></author><author><name sortKey="Chakkour, Hp" uniqKey="Chakkour H">HP Chakkour</name></author><author><name sortKey="Viana Vdos, S" uniqKey="Viana Vdos S">S Viana Vdos</name></author><author><name sortKey="Bueno, C" uniqKey="Bueno C">C Bueno</name></author><author><name sortKey="Leon, Ep" uniqKey="Leon E">EP Leon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pender, Mp" uniqKey="Pender M">MP Pender</name></author><author><name sortKey="Burrows, Sr" uniqKey="Burrows S">SR Burrows</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Handel, Ae" uniqKey="Handel A">AE Handel</name></author><author><name sortKey="Williamson, Aj" uniqKey="Williamson A">AJ Williamson</name></author><author><name sortKey="Disanto, G" uniqKey="Disanto G">G Disanto</name></author><author><name sortKey="Handunnetthi, L" uniqKey="Handunnetthi L">L Handunnetthi</name></author><author><name sortKey="Giovannoni, G" uniqKey="Giovannoni G">G Giovannoni</name></author><author><name sortKey="Ramagopalan, Sv" uniqKey="Ramagopalan S">SV Ramagopalan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ruprecht, K" uniqKey="Ruprecht K">K Ruprecht</name></author><author><name sortKey="Wunderlich, B" uniqKey="Wunderlich B">B Wunderlich</name></author><author><name sortKey="Giess, R" uniqKey="Giess R">R Giess</name></author><author><name sortKey="Meyer, P" uniqKey="Meyer P">P Meyer</name></author><author><name sortKey="Loebel, M" uniqKey="Loebel M">M Loebel</name></author><author><name sortKey="Lenz, K" uniqKey="Lenz K">K Lenz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ascherio, A" uniqKey="Ascherio A">A Ascherio</name></author><author><name sortKey="Munger, Kl" uniqKey="Munger K">KL Munger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gabibov, Ag" uniqKey="Gabibov A">AG Gabibov</name></author><author><name sortKey="Belogurov, Aa" uniqKey="Belogurov A">AA Belogurov</name></author><author><name sortKey="Lomakin, Ya" uniqKey="Lomakin Y">YA Lomakin</name></author><author><name sortKey="Zakharova, My" uniqKey="Zakharova M">MY Zakharova</name></author><author><name sortKey="Avakyan, Me" uniqKey="Avakyan M">ME Avakyan</name></author><author><name sortKey="Dubrovskaya, Vv" uniqKey="Dubrovskaya V">VV Dubrovskaya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheng, W" uniqKey="Cheng W">W Cheng</name></author><author><name sortKey="Ma, Y" uniqKey="Ma Y">Y Ma</name></author><author><name sortKey="Gong, F" uniqKey="Gong F">F Gong</name></author><author><name sortKey="Hu, C" uniqKey="Hu C">C Hu</name></author><author><name sortKey="Qian, L" uniqKey="Qian L">L Qian</name></author><author><name sortKey="Huang, Q" uniqKey="Huang Q">Q Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poole, Bd" uniqKey="Poole B">BD Poole</name></author><author><name sortKey="Gross, T" uniqKey="Gross T">T Gross</name></author><author><name sortKey="Maier, S" uniqKey="Maier S">S Maier</name></author><author><name sortKey="Harley, Jb" uniqKey="Harley J">JB Harley</name></author><author><name sortKey="James, Ja" uniqKey="James J">JA James</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Carruthers, Bm" uniqKey="Carruthers B">BM Carruthers</name></author><author><name sortKey="Van De Sande, Mi" uniqKey="Van De Sande M">MI van de Sande</name></author><author><name sortKey="De Meirleir, Kl" uniqKey="De Meirleir K">KL De Meirleir</name></author><author><name sortKey="Klimas, Ng" uniqKey="Klimas N">NG Klimas</name></author><author><name sortKey="Broderick, G" uniqKey="Broderick G">G Broderick</name></author><author><name sortKey="Mitchell, T" uniqKey="Mitchell T">T Mitchell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Christley, Y" uniqKey="Christley Y">Y Christley</name></author><author><name sortKey="Duffy, T" uniqKey="Duffy T">T Duffy</name></author><author><name sortKey="Everall, Ip" uniqKey="Everall I">IP Everall</name></author><author><name sortKey="Martin, Cr" uniqKey="Martin C">CR Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tanaka, Y" uniqKey="Tanaka Y">Y Tanaka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bansal, As" uniqKey="Bansal A">AS Bansal</name></author><author><name sortKey="Bradley, As" uniqKey="Bradley A">AS Bradley</name></author><author><name sortKey="Bishop, Kn" uniqKey="Bishop K">KN Bishop</name></author><author><name sortKey="Kiani Alikhan, S" uniqKey="Kiani Alikhan S">S Kiani-Alikhan</name></author><author><name sortKey="Ford, B" uniqKey="Ford B">B Ford</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shepherd, C" uniqKey="Shepherd C">C Shepherd</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jason, La" uniqKey="Jason L">LA Jason</name></author><author><name sortKey="Torres Harding, Sr" uniqKey="Torres Harding S">SR Torres-Harding</name></author><author><name sortKey="Carrico, Aw" uniqKey="Carrico A">AW Carrico</name></author><author><name sortKey="Taylor, Rr" uniqKey="Taylor R">RR Taylor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scheibenbogen, C" uniqKey="Scheibenbogen C">C Scheibenbogen</name></author><author><name sortKey="Volk, H" uniqKey="Volk H">H Volk</name></author><author><name sortKey="Grabowski, P" uniqKey="Grabowski P">P Grabowski</name></author><author><name sortKey="Wittke, K" uniqKey="Wittke K">K Wittke</name></author><author><name sortKey="Giannini, C" uniqKey="Giannini C">C Giannini</name></author><author><name sortKey="Hoffmeister, B" uniqKey="Hoffmeister B">B Hoffmeister</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maher, Kj" uniqKey="Maher K">KJ Maher</name></author><author><name sortKey="Klimas, Ng" uniqKey="Klimas N">NG Klimas</name></author><author><name sortKey="Fletcher, Ma" uniqKey="Fletcher M">MA Fletcher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jason, La" uniqKey="Jason L">LA Jason</name></author><author><name sortKey="Fricano, G" uniqKey="Fricano G">G Fricano</name></author><author><name sortKey="Taylor, Rr" uniqKey="Taylor R">RR Taylor</name></author><author><name sortKey="Halpert, J" uniqKey="Halpert J">J Halpert</name></author><author><name sortKey="Fennell, Pa" uniqKey="Fennell P">PA Fennell</name></author><author><name sortKey="Klein, S" uniqKey="Klein S">S Klein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brenu, Ew" uniqKey="Brenu E">EW Brenu</name></author><author><name sortKey="Van Driel, Ml" uniqKey="Van Driel M">ML van Driel</name></author><author><name sortKey="Staines, Dr" uniqKey="Staines D">DR Staines</name></author><author><name sortKey="Ashton, Kj" uniqKey="Ashton K">KJ Ashton</name></author><author><name sortKey="Ramos, Sb" uniqKey="Ramos S">SB Ramos</name></author><author><name sortKey="Keane, J" uniqKey="Keane J">J Keane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dubois, Re" uniqKey="Dubois R">RE DuBois</name></author><author><name sortKey="Seeley, Jk" uniqKey="Seeley J">JK Seeley</name></author><author><name sortKey="Brus, I" uniqKey="Brus I">I Brus</name></author><author><name sortKey="Sakamoto, K" uniqKey="Sakamoto K">K Sakamoto</name></author><author><name sortKey="Ballow, M" uniqKey="Ballow M">M Ballow</name></author><author><name sortKey="Harada, S" uniqKey="Harada S">S Harada</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Komaroff, Al" uniqKey="Komaroff A">AL Komaroff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Straus, Se" uniqKey="Straus S">SE Straus</name></author><author><name sortKey="Dale, Jk" uniqKey="Dale J">JK Dale</name></author><author><name sortKey="Tobi, M" uniqKey="Tobi M">M Tobi</name></author><author><name sortKey="Lawley, T" uniqKey="Lawley T">T Lawley</name></author><author><name sortKey="Preble, O" uniqKey="Preble O">O Preble</name></author><author><name sortKey="Blaese, Rm" uniqKey="Blaese R">RM Blaese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lerner, Am" uniqKey="Lerner A">AM Lerner</name></author><author><name sortKey="Beqaj, Sh" uniqKey="Beqaj S">SH Beqaj</name></author><author><name sortKey="Deeter, Rg" uniqKey="Deeter R">RG Deeter</name></author><author><name sortKey="Fitzgerald, Jt" uniqKey="Fitzgerald J">JT Fitzgerald</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Montoya, Jg" uniqKey="Montoya J">JG Montoya</name></author><author><name sortKey="Kogelnik, Am" uniqKey="Kogelnik A">AM Kogelnik</name></author><author><name sortKey="Bhangoo, M" uniqKey="Bhangoo M">M Bhangoo</name></author><author><name sortKey="Lunn, Mr" uniqKey="Lunn M">MR Lunn</name></author><author><name sortKey="Flamand, L" uniqKey="Flamand L">L Flamand</name></author><author><name sortKey="Merrihew, Le" uniqKey="Merrihew L">LE Merrihew</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Straus, Se" uniqKey="Straus S">SE Straus</name></author><author><name sortKey="Tosato, G" uniqKey="Tosato G">G Tosato</name></author><author><name sortKey="Armstrong, G" uniqKey="Armstrong G">G Armstrong</name></author><author><name sortKey="Lawley, T" uniqKey="Lawley T">T Lawley</name></author><author><name sortKey="Preble, Ot" uniqKey="Preble O">OT Preble</name></author><author><name sortKey="Henle, W" uniqKey="Henle W">W Henle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jones, Jf" uniqKey="Jones J">JF Jones</name></author><author><name sortKey="Williams, M" uniqKey="Williams M">M Williams</name></author><author><name sortKey="Schooley, Rt" uniqKey="Schooley R">RT Schooley</name></author><author><name sortKey="Robinson, C" uniqKey="Robinson C">C Robinson</name></author><author><name sortKey="Glaser, R" uniqKey="Glaser R">R Glaser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buchwald, D" uniqKey="Buchwald D">D Buchwald</name></author><author><name sortKey="Sullivan, Jl" uniqKey="Sullivan J">JL Sullivan</name></author><author><name sortKey="Komaroff, Al" uniqKey="Komaroff A">AL Komaroff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hellinger, Wc" uniqKey="Hellinger W">WC Hellinger</name></author><author><name sortKey="Smith, Tf" uniqKey="Smith T">TF Smith</name></author><author><name sortKey="Van Scoy, Re" uniqKey="Van Scoy R">RE Van Scoy</name></author><author><name sortKey="Spitzer, Pg" uniqKey="Spitzer P">PG Spitzer</name></author><author><name sortKey="Forgacs, P" uniqKey="Forgacs P">P Forgacs</name></author><author><name sortKey="Edson, Rs" uniqKey="Edson R">RS Edson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holmes, Gp" uniqKey="Holmes G">GP Holmes</name></author><author><name sortKey="Kaplan, Je" uniqKey="Kaplan J">JE Kaplan</name></author><author><name sortKey="Stewart, Ja" uniqKey="Stewart J">JA Stewart</name></author><author><name sortKey="Hunt, B" uniqKey="Hunt B">B Hunt</name></author><author><name sortKey="Pinsky, Pf" uniqKey="Pinsky P">PF Pinsky</name></author><author><name sortKey="Schonberger, Lb" uniqKey="Schonberger L">LB Schonberger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lerner, Am" uniqKey="Lerner A">AM Lerner</name></author><author><name sortKey="Beqaj, Sh" uniqKey="Beqaj S">SH Beqaj</name></author><author><name sortKey="Deeter, Rg" uniqKey="Deeter R">RG Deeter</name></author><author><name sortKey="Fitzgerald, Jt" uniqKey="Fitzgerald J">JT Fitzgerald</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lerner, Am" uniqKey="Lerner A">AM Lerner</name></author><author><name sortKey="Ariza, Me" uniqKey="Ariza M">ME Ariza</name></author><author><name sortKey="Williams, M" uniqKey="Williams M">M Williams</name></author><author><name sortKey="Jason, L" uniqKey="Jason L">L Jason</name></author><author><name sortKey="Beqaj, S" uniqKey="Beqaj S">S Beqaj</name></author><author><name sortKey="Fitzgerald, Jt" uniqKey="Fitzgerald J">JT Fitzgerald</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sairenji, T" uniqKey="Sairenji T">T Sairenji</name></author><author><name sortKey="Yamanishi, K" uniqKey="Yamanishi K">K Yamanishi</name></author><author><name sortKey="Tachibana, Y" uniqKey="Tachibana Y">Y Tachibana</name></author><author><name sortKey="Bertoni, G" uniqKey="Bertoni G">G Bertoni</name></author><author><name sortKey="Kurata, T" uniqKey="Kurata T">T Kurata</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kawai, K" uniqKey="Kawai K">K Kawai</name></author><author><name sortKey="Kawai, A" uniqKey="Kawai A">A Kawai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cameron, B" uniqKey="Cameron B">B Cameron</name></author><author><name sortKey="Flamand, L" uniqKey="Flamand L">L Flamand</name></author><author><name sortKey="Juwana, H" uniqKey="Juwana H">H Juwana</name></author><author><name sortKey="Middeldorp, J" uniqKey="Middeldorp J">J Middeldorp</name></author><author><name sortKey="Naing, Z" uniqKey="Naing Z">Z Naing</name></author><author><name sortKey="Rawlinson, W" uniqKey="Rawlinson W">W Rawlinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wallace, Hl" uniqKey="Wallace H">HL Wallace</name></author><author><name sortKey="Natelson, B" uniqKey="Natelson B">B Natelson</name></author><author><name sortKey="Gause, W" uniqKey="Gause W">W Gause</name></author><author><name sortKey="Hay, J" uniqKey="Hay J">J Hay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Whelton, Cl" uniqKey="Whelton C">CL Whelton</name></author><author><name sortKey="Salit, I" uniqKey="Salit I">I Salit</name></author><author><name sortKey="Moldofsky, H" uniqKey="Moldofsky H">H Moldofsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Loebel, M" uniqKey="Loebel M">M Loebel</name></author><author><name sortKey="Strohschein, K" uniqKey="Strohschein K">K Strohschein</name></author><author><name sortKey="Giannini, C" uniqKey="Giannini C">C Giannini</name></author><author><name sortKey="Koelsch, U" uniqKey="Koelsch U">U Koelsch</name></author><author><name sortKey="Bauer, S" uniqKey="Bauer S">S Bauer</name></author><author><name sortKey="Doebis, C" uniqKey="Doebis C">C Doebis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miller, G" uniqKey="Miller G">G Miller</name></author><author><name sortKey="Grogan, E" uniqKey="Grogan E">E Grogan</name></author><author><name sortKey="Fischer, Dk" uniqKey="Fischer D">DK Fischer</name></author><author><name sortKey="Niederman, Jc" uniqKey="Niederman J">JC Niederman</name></author><author><name sortKey="Schooley, Rt" uniqKey="Schooley R">RT Schooley</name></author><author><name sortKey="Henle, W" uniqKey="Henle W">W Henle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Henle, W" uniqKey="Henle W">W Henle</name></author><author><name sortKey="Henle, G" uniqKey="Henle G">G Henle</name></author><author><name sortKey="Andersson, J" uniqKey="Andersson J">J Andersson</name></author><author><name sortKey="Ernberg, I" uniqKey="Ernberg I">I Ernberg</name></author><author><name sortKey="Klein, G" uniqKey="Klein G">G Klein</name></author><author><name sortKey="Horwitz, Ca" uniqKey="Horwitz C">CA Horwitz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sample, J" uniqKey="Sample J">J Sample</name></author><author><name sortKey="Young, L" uniqKey="Young L">L Young</name></author><author><name sortKey="Martin, B" uniqKey="Martin B">B Martin</name></author><author><name sortKey="Chatman, T" uniqKey="Chatman T">T Chatman</name></author><author><name sortKey="Kieff, E" uniqKey="Kieff E">E Kieff</name></author><author><name sortKey="Rickinson, A" uniqKey="Rickinson A">A Rickinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bornkamm, Gw" uniqKey="Bornkamm G">GW Bornkamm</name></author><author><name sortKey="Delius, H" uniqKey="Delius H">H Delius</name></author><author><name sortKey="Zimber, U" uniqKey="Zimber U">U Zimber</name></author><author><name sortKey="Hudewentz, J" uniqKey="Hudewentz J">J Hudewentz</name></author><author><name sortKey="Epstein, Ma" uniqKey="Epstein M">MA Epstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baer, R" uniqKey="Baer R">R Baer</name></author><author><name sortKey="Bankier, At" uniqKey="Bankier A">AT Bankier</name></author><author><name sortKey="Biggin, Md" uniqKey="Biggin M">MD Biggin</name></author><author><name sortKey="Deininger, Pl" uniqKey="Deininger P">PL Deininger</name></author><author><name sortKey="Farrell, Pj" uniqKey="Farrell P">PJ Farrell</name></author><author><name sortKey="Gibson, Tj" uniqKey="Gibson T">TJ Gibson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walling, Dm" uniqKey="Walling D">DM Walling</name></author><author><name sortKey="Flaitz, Cm" uniqKey="Flaitz C">CM Flaitz</name></author><author><name sortKey="Nichols, Cm" uniqKey="Nichols C">CM Nichols</name></author><author><name sortKey="Hudnall, Sd" uniqKey="Hudnall S">SD Hudnall</name></author><author><name sortKey="Adler Storthz, K" uniqKey="Adler Storthz K">K Adler-Storthz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Herrmann, K" uniqKey="Herrmann K">K Herrmann</name></author><author><name sortKey="Frangou, P" uniqKey="Frangou P">P Frangou</name></author><author><name sortKey="Middeldorp, J" uniqKey="Middeldorp J">J Middeldorp</name></author><author><name sortKey="Niedobitek, G" uniqKey="Niedobitek G">G Niedobitek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frangou, P" uniqKey="Frangou P">P Frangou</name></author><author><name sortKey="Buettner, M" uniqKey="Buettner M">M Buettner</name></author><author><name sortKey="Niedobitek, G" uniqKey="Niedobitek G">G Niedobitek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Greenspan, Js" uniqKey="Greenspan J">JS Greenspan</name></author><author><name sortKey="Greenspan, D" uniqKey="Greenspan D">D Greenspan</name></author><author><name sortKey="Lennette, Et" uniqKey="Lennette E">ET Lennette</name></author><author><name sortKey="Abrams, Di" uniqKey="Abrams D">DI Abrams</name></author><author><name sortKey="Conant, Ma" uniqKey="Conant M">MA Conant</name></author><author><name sortKey="Petersen, V" uniqKey="Petersen V">V Petersen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sixbey, Jw" uniqKey="Sixbey J">JW Sixbey</name></author><author><name sortKey="Nedrud, Jg" uniqKey="Nedrud J">JG Nedrud</name></author><author><name sortKey="Raab Traub, N" uniqKey="Raab Traub N">N Raab-Traub</name></author><author><name sortKey="Hanes, Ra" uniqKey="Hanes R">RA Hanes</name></author><author><name sortKey="Pagano, Js" uniqKey="Pagano J">JS Pagano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nilsson, K" uniqKey="Nilsson K">K Nilsson</name></author><author><name sortKey="Klein, G" uniqKey="Klein G">G Klein</name></author><author><name sortKey="Henle, W" uniqKey="Henle W">W Henle</name></author><author><name sortKey="Henle, G" uniqKey="Henle G">G Henle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yates, J" uniqKey="Yates J">J Yates</name></author><author><name sortKey="Warren, N" uniqKey="Warren N">N Warren</name></author><author><name sortKey="Reisman, D" uniqKey="Reisman D">D Reisman</name></author><author><name sortKey="Sugden, B" uniqKey="Sugden B">B Sugden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Altmann, M" uniqKey="Altmann M">M Altmann</name></author><author><name sortKey="Pich, D" uniqKey="Pich D">D Pich</name></author><author><name sortKey="Ruiss, R" uniqKey="Ruiss R">R Ruiss</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name></author><author><name sortKey="Sugden, B" uniqKey="Sugden B">B Sugden</name></author><author><name sortKey="Hammerschmidt, W" uniqKey="Hammerschmidt W">W Hammerschmidt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Babcock, Gj" uniqKey="Babcock G">GJ Babcock</name></author><author><name sortKey="Decker, Ll" uniqKey="Decker L">LL Decker</name></author><author><name sortKey="Volk, M" uniqKey="Volk M">M Volk</name></author><author><name sortKey="Thorley Lawson, Da" uniqKey="Thorley Lawson D">DA Thorley-Lawson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cohen, Ji" uniqKey="Cohen J">JI Cohen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rezk, Sa" uniqKey="Rezk S">SA Rezk</name></author><author><name sortKey="Weiss, Lm" uniqKey="Weiss L">LM Weiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klein, G" uniqKey="Klein G">G Klein</name></author><author><name sortKey="Klein, E" uniqKey="Klein E">E Klein</name></author><author><name sortKey="Kashuba, E" uniqKey="Kashuba E">E Kashuba</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsurumi, T" uniqKey="Tsurumi T">T Tsurumi</name></author><author><name sortKey="Fujita, M" uniqKey="Fujita M">M Fujita</name></author><author><name sortKey="Kudoh, A" uniqKey="Kudoh A">A Kudoh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gorzer, I" uniqKey="Gorzer I">I Görzer</name></author><author><name sortKey="Niesters, Hgm" uniqKey="Niesters H">HGM Niesters</name></author><author><name sortKey="Cornelissen, Jj" uniqKey="Cornelissen J">JJ Cornelissen</name></author><author><name sortKey="Puchhammer Stockl, E" uniqKey="Puchhammer Stockl E">E Puchhammer-Stöckl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lucchesi, W" uniqKey="Lucchesi W">W Lucchesi</name></author><author><name sortKey="Brady, G" uniqKey="Brady G">G Brady</name></author><author><name sortKey="Dittrich Breiholz, O" uniqKey="Dittrich Breiholz O">O Dittrich-Breiholz</name></author><author><name sortKey="Kracht, M" uniqKey="Kracht M">M Kracht</name></author><author><name sortKey="Russ, R" uniqKey="Russ R">R Russ</name></author><author><name sortKey="Farrell, Pj" uniqKey="Farrell P">PJ Farrell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carruthers, Bm Ja" uniqKey="Carruthers B">BM JA Carruthers</name></author><author><name sortKey="De Meirleir, Kl" uniqKey="De Meirleir K">KL De Meirleir</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cello, J" uniqKey="Cello J">J Cello</name></author><author><name sortKey="Samuelson, A" uniqKey="Samuelson A">A Samuelson</name></author><author><name sortKey="Stalhandske, P" uniqKey="Stalhandske P">P Stalhandske</name></author><author><name sortKey="Svennerholm, B" uniqKey="Svennerholm B">B Svennerholm</name></author><author><name sortKey="Jeansson, S" uniqKey="Jeansson S">S Jeansson</name></author><author><name sortKey="Forsgren, M" uniqKey="Forsgren M">M Forsgren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zerweck, J" uniqKey="Zerweck J">J Zerweck</name></author><author><name sortKey="Reimer, U" uniqKey="Reimer U">U Reimer</name></author><author><name sortKey="Jansong, J" uniqKey="Jansong J">J Jansong</name></author><author><name sortKey="Pawlowski, N" uniqKey="Pawlowski N">N Pawlowski</name></author><author><name sortKey="Tersch, C" uniqKey="Tersch C">C Tersch</name></author><author><name sortKey="Eckey, M" uniqKey="Eckey M">M Eckey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fluge, O" uniqKey="Fluge O">O Fluge</name></author><author><name sortKey="Mella, O" uniqKey="Mella O">O Mella</name></author><author><name sortKey="Bruland, O" uniqKey="Bruland O">O Bruland</name></author><author><name sortKey="Risa, K" uniqKey="Risa K">K Risa</name></author><author><name sortKey="Dyrstad, Se" uniqKey="Dyrstad S">SE Dyrstad</name></author><author><name sortKey="Alme, K" uniqKey="Alme K">K Alme</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamano, E" uniqKey="Yamano E">E Yamano</name></author><author><name sortKey="Sugimoto, M" uniqKey="Sugimoto M">M Sugimoto</name></author><author><name sortKey="Hirayama, A" uniqKey="Hirayama A">A Hirayama</name></author><author><name sortKey="Kume, S" uniqKey="Kume S">S Kume</name></author><author><name sortKey="Yamato, M" uniqKey="Yamato M">M Yamato</name></author><author><name sortKey="Jin, G" uniqKey="Jin G">G Jin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zivadinov, R" uniqKey="Zivadinov R">R Zivadinov</name></author><author><name sortKey="Cerza, N" uniqKey="Cerza N">N Cerza</name></author><author><name sortKey="Hagemeier, J" uniqKey="Hagemeier J">J Hagemeier</name></author><author><name sortKey="Carl, E" uniqKey="Carl E">E Carl</name></author><author><name sortKey="Badgett, D" uniqKey="Badgett D">D Badgett</name></author><author><name sortKey="Ramasamy, Dp" uniqKey="Ramasamy D">DP Ramasamy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fattal, I" uniqKey="Fattal I">I Fattal</name></author><author><name sortKey="Shental, N" uniqKey="Shental N">N Shental</name></author><author><name sortKey="Molad, Y" uniqKey="Molad Y">Y Molad</name></author><author><name sortKey="Gabrielli, A" uniqKey="Gabrielli A">A Gabrielli</name></author><author><name sortKey="Pokroy Shapira, E" uniqKey="Pokroy Shapira E">E Pokroy-Shapira</name></author><author><name sortKey="Oren, S" uniqKey="Oren S">S Oren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Csuka, D" uniqKey="Csuka D">D Csuka</name></author><author><name sortKey="Banati, M" uniqKey="Banati M">M Banati</name></author><author><name sortKey="Rozsa, C" uniqKey="Rozsa C">C Rozsa</name></author><author><name sortKey="Fust, G" uniqKey="Fust G">G Fust</name></author><author><name sortKey="Illes, Z" uniqKey="Illes Z">Z Illes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Esen, Ba" uniqKey="Esen B">BA Esen</name></author><author><name sortKey="Yilmaz, G" uniqKey="Yilmaz G">G Yilmaz</name></author><author><name sortKey="Uzun, S" uniqKey="Uzun S">S Uzun</name></author><author><name sortKey="Ozdamar, M" uniqKey="Ozdamar M">M Ozdamar</name></author><author><name sortKey="Aksozek, A" uniqKey="Aksozek A">A Aksozek</name></author><author><name sortKey="Kamali, S" uniqKey="Kamali S">S Kamali</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Castellazzi, M" uniqKey="Castellazzi M">M Castellazzi</name></author><author><name sortKey="Tamborino, C" uniqKey="Tamborino C">C Tamborino</name></author><author><name sortKey="Cani, A" uniqKey="Cani A">A Cani</name></author><author><name sortKey="Negri, E" uniqKey="Negri E">E Negri</name></author><author><name sortKey="Baldi, E" uniqKey="Baldi E">E Baldi</name></author><author><name sortKey="Seraceni, S" uniqKey="Seraceni S">S Seraceni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fachiroh, J" uniqKey="Fachiroh J">J Fachiroh</name></author><author><name sortKey="Schouten, T" uniqKey="Schouten T">T Schouten</name></author><author><name sortKey="Hariwiyanto, B" uniqKey="Hariwiyanto B">B Hariwiyanto</name></author><author><name sortKey="Paramita, Dk" uniqKey="Paramita D">DK Paramita</name></author><author><name sortKey="Harijadi, A" uniqKey="Harijadi A">A Harijadi</name></author><author><name sortKey="Haryana, Sm" uniqKey="Haryana S">SM Haryana</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yip, Tt" uniqKey="Yip T">TT Yip</name></author><author><name sortKey="Ngan, Rk" uniqKey="Ngan R">RK Ngan</name></author><author><name sortKey="Lau, Wh" uniqKey="Lau W">WH Lau</name></author><author><name sortKey="Poon, Yf" uniqKey="Poon Y">YF Poon</name></author><author><name sortKey="Joab, I" uniqKey="Joab I">I Joab</name></author><author><name sortKey="Cochet, C" uniqKey="Cochet C">C Cochet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rajnavolgyi, E" uniqKey="Rajnavolgyi E">E Rajnavolgyi</name></author><author><name sortKey="Nagy, N" uniqKey="Nagy N">N Nagy</name></author><author><name sortKey="Thuresson, B" uniqKey="Thuresson B">B Thuresson</name></author><author><name sortKey="Dosztanyi, Z" uniqKey="Dosztanyi Z">Z Dosztanyi</name></author><author><name sortKey="Simon, A" uniqKey="Simon A">A Simon</name></author><author><name sortKey="Simon, I" uniqKey="Simon I">I Simon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Draborg, Ah" uniqKey="Draborg A">AH Draborg</name></author><author><name sortKey="Jorgensen, Jm" uniqKey="Jorgensen J">JM Jorgensen</name></author><author><name sortKey="Muller, H" uniqKey="Muller H">H Muller</name></author><author><name sortKey="Nielsen, Ct" uniqKey="Nielsen C">CT Nielsen</name></author><author><name sortKey="Jacobsen, S" uniqKey="Jacobsen S">S Jacobsen</name></author><author><name sortKey="Iversen, Lv" uniqKey="Iversen L">LV Iversen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Larsen, M" uniqKey="Larsen M">M Larsen</name></author><author><name sortKey="Sauce, D" uniqKey="Sauce D">D Sauce</name></author><author><name sortKey="Deback, C" uniqKey="Deback C">C Deback</name></author><author><name sortKey="Arnaud, L" uniqKey="Arnaud L">L Arnaud</name></author><author><name sortKey="Mathian, A" uniqKey="Mathian A">A Mathian</name></author><author><name sortKey="Miyara, M" uniqKey="Miyara M">M Miyara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcclain, Mt" uniqKey="Mcclain M">MT McClain</name></author><author><name sortKey="Heinlen, Ld" uniqKey="Heinlen L">LD Heinlen</name></author><author><name sortKey="Dennis, Gj" uniqKey="Dennis G">GJ Dennis</name></author><author><name sortKey="Roebuck, J" uniqKey="Roebuck J">J Roebuck</name></author><author><name sortKey="Harley, Jb" uniqKey="Harley J">JB Harley</name></author><author><name sortKey="James, Ja" uniqKey="James J">JA James</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ostdal, H" uniqKey="Ostdal H">H Ostdal</name></author><author><name sortKey="Bjerrum, Mj" uniqKey="Bjerrum M">MJ Bjerrum</name></author><author><name sortKey="Pedersen, Ja" uniqKey="Pedersen J">JA Pedersen</name></author><author><name sortKey="Andersen, Hj" uniqKey="Andersen H">HJ Andersen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Almehdar, Ha" uniqKey="Almehdar H">HA Almehdar</name></author><author><name sortKey="El Fakharany, Em" uniqKey="El Fakharany E">EM El-Fakharany</name></author><author><name sortKey="Uversky, Vn" uniqKey="Uversky V">VN Uversky</name></author><author><name sortKey="Redwan, Em" uniqKey="Redwan E">EM Redwan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thomas, El" uniqKey="Thomas E">EL Thomas</name></author><author><name sortKey="Aune, Tm" uniqKey="Aune T">TM Aune</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Loebel, M" uniqKey="Loebel M">M Loebel</name></author><author><name sortKey="Grabowski, P" uniqKey="Grabowski P">P Grabowski</name></author><author><name sortKey="Heidecke, H" uniqKey="Heidecke H">H Heidecke</name></author><author><name sortKey="Bauer, S" uniqKey="Bauer S">S Bauer</name></author><author><name sortKey="Hanitsch, Lg" uniqKey="Hanitsch L">LG Hanitsch</name></author><author><name sortKey="Wittke, K" uniqKey="Wittke K">K Wittke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garcia Cosio, M" uniqKey="Garcia Cosio M">M Garcia-Cosio</name></author><author><name sortKey="Santon, A" uniqKey="Santon A">A Santon</name></author><author><name sortKey="Martin, P" uniqKey="Martin P">P Martin</name></author><author><name sortKey="Reguero, Me" uniqKey="Reguero M">ME Reguero</name></author><author><name sortKey="Cristobal, E" uniqKey="Cristobal E">E Cristobal</name></author><author><name sortKey="Bellas, C" uniqKey="Bellas C">C Bellas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ibrahim, Ha" uniqKey="Ibrahim H">HA Ibrahim</name></author><author><name sortKey="Menasce, Lp" uniqKey="Menasce L">LP Menasce</name></author><author><name sortKey="Pomplun, S" uniqKey="Pomplun S">S Pomplun</name></author><author><name sortKey="Burke, M" uniqKey="Burke M">M Burke</name></author><author><name sortKey="Bower, M" uniqKey="Bower M">M Bower</name></author><author><name sortKey="Naresh, Kn" uniqKey="Naresh K">KN Naresh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Conacher, M" uniqKey="Conacher M">M Conacher</name></author><author><name sortKey="Callard, R" uniqKey="Callard R">R Callard</name></author><author><name sortKey="Mcaulay, K" uniqKey="Mcaulay K">K McAulay</name></author><author><name sortKey="Chapel, H" uniqKey="Chapel H">H Chapel</name></author><author><name sortKey="Webster, D" uniqKey="Webster D">D Webster</name></author><author><name sortKey="Kumararatne, D" uniqKey="Kumararatne D">D Kumararatne</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bavière</li><li>Berlin</li><li>District de Haute-Bavière</li></region><settlement><li>Berlin</li><li>Munich</li></settlement><orgName><li>Université technique de Munich</li></orgName></list><tree><country name="Allemagne"><region name="Berlin"><name sortKey="Loebel, Madlen" sort="Loebel, Madlen" uniqKey="Loebel M" first="Madlen" last="Loebel">Madlen Loebel</name></region><name sortKey="Bauer, Sandra" sort="Bauer, Sandra" uniqKey="Bauer S" first="Sandra" last="Bauer">Sandra Bauer</name><name sortKey="Behrends, Uta" sort="Behrends, Uta" uniqKey="Behrends U" first="Uta" last="Behrends">Uta Behrends</name><name sortKey="Behrends, Uta" sort="Behrends, Uta" uniqKey="Behrends U" first="Uta" last="Behrends">Uta Behrends</name><name sortKey="Behrends, Uta" sort="Behrends, Uta" uniqKey="Behrends U" first="Uta" last="Behrends">Uta Behrends</name><name sortKey="Borchmann, Peter" sort="Borchmann, Peter" uniqKey="Borchmann P" first="Peter" last="Borchmann">Peter Borchmann</name><name sortKey="Eckey, Maren" sort="Eckey, Maren" uniqKey="Eckey M" first="Maren" last="Eckey">Maren Eckey</name><name sortKey="Grabowski, Patricia" sort="Grabowski, Patricia" uniqKey="Grabowski P" first="Patricia" last="Grabowski">Patricia Grabowski</name><name sortKey="Hahn, Elisabeth" sort="Hahn, Elisabeth" uniqKey="Hahn E" first="Elisabeth" last="Hahn">Elisabeth Hahn</name><name sortKey="Hanitsch, Leif G" sort="Hanitsch, Leif G" uniqKey="Hanitsch L" first="Leif G." last="Hanitsch">Leif G. Hanitsch</name><name sortKey="Hiepe, Falk" sort="Hiepe, Falk" uniqKey="Hiepe F" first="Falk" last="Hiepe">Falk Hiepe</name><name sortKey="Holenya, Pavlo" sort="Holenya, Pavlo" uniqKey="Holenya P" first="Pavlo" last="Holenya">Pavlo Holenya</name><name sortKey="Meindl, Carola" sort="Meindl, Carola" uniqKey="Meindl C" first="Carola" last="Meindl">Carola Meindl</name><name sortKey="Meindl, Carola" sort="Meindl, Carola" uniqKey="Meindl C" first="Carola" last="Meindl">Carola Meindl</name><name sortKey="Reimer, Ulf" sort="Reimer, Ulf" uniqKey="Reimer U" first="Ulf" last="Reimer">Ulf Reimer</name><name sortKey="Ruffer, Jens Ulrich" sort="Ruffer, Jens Ulrich" uniqKey="Ruffer J" first="Jens-Ulrich" last="Rüffer">Jens-Ulrich Rüffer</name><name sortKey="Ruprecht, Klemens" sort="Ruprecht, Klemens" uniqKey="Ruprecht K" first="Klemens" last="Ruprecht">Klemens Ruprecht</name><name sortKey="Scheibenbogen, Carmen" sort="Scheibenbogen, Carmen" uniqKey="Scheibenbogen C" first="Carmen" last="Scheibenbogen">Carmen Scheibenbogen</name><name sortKey="Scheibenbogen, Carmen" sort="Scheibenbogen, Carmen" uniqKey="Scheibenbogen C" first="Carmen" last="Scheibenbogen">Carmen Scheibenbogen</name><name sortKey="Sotzny, Franziska" sort="Sotzny, Franziska" uniqKey="Sotzny F" first="Franziska" last="Sotzny">Franziska Sotzny</name><name sortKey="Volk, Hans Dieter" sort="Volk, Hans Dieter" uniqKey="Volk H" first="Hans-Dieter" last="Volk">Hans-Dieter Volk</name><name sortKey="Volk, Hans Dieter" sort="Volk, Hans Dieter" uniqKey="Volk H" first="Hans-Dieter" last="Volk">Hans-Dieter Volk</name><name sortKey="Wittke, Kirsten" sort="Wittke, Kirsten" uniqKey="Wittke K" first="Kirsten" last="Wittke">Kirsten Wittke</name><name sortKey="Zerweck, Johannes" sort="Zerweck, Johannes" uniqKey="Zerweck J" first="Johannes" last="Zerweck">Johannes Zerweck</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B94 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000B94 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:5467847
|texte= Serological profiling of the EBV immune response in Chronic Fatigue Syndrome using a peptide microarray
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:28604802" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |